Compression, Mechanical and Release Properties of Chloroquine Phosphate Tablets containing corn and Trifoliate Yam Starches as Binders

 

 Oladapo A. Adetunji, Michael A. Odeniyi and Oludele A. Itiola*

Department of Pharmaceutics & Industrial Pharmacy,  Faculty of Pharmacy, University of Ibadan, Nigeria

 

Tropical Journal of Pharmaceutical Research 2006; 5(2): 589-596

ISSN: 1596-599

 

Abstract

 

Purpose: A study was made of the binding properties of trifoliate yam starch, obtained from Dioscorea dumetorum (Pax), in chloroquine phosphate tablet formulations in comparison with official corn starch.

 

Method: Compressional properties were analyzed using density measurements and compression equations of Heckel and Kawakita. The mechanical properties of the tablets were assessed using the crushing strength and friability of the tablets, while drug release properties of the tablets were assessed using disintegration and dissolution times.

 

Results: Tablet formulations containing trifoliate yam starch exhibited faster onset and higher amount of plastic deformation during compression than those containing corn starch. The crushing strength, disintegration and dissolution times of the tablets increased with binder concentration while friability values decreased. Trifoliate yam starch produced tablets with stronger mechanical properties and longer disintegration and dissolution times than those containing corn starch.

 

Conclusion: Trifoliate yam starch would be a better alternative to corn starch in producing uncoated tablets for which high bond strength is essential. 

 

 

Keywords: Trifoliate yam starch, corn starch, binding agent, compression, Heckel equation, Kawakita equation, mechanical properties, drug release.

 

*Corresponding Author:  E-mail:  oprofit@yahoo.com