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Research Article

 

 

Antimicrobial activity of the ethanol extract of the aerial parts of sida acuta burm.f. (malvaceae)

 

IE Oboh1, JO Akerele2* and O Obasuyi2

1 Department of Pharmacognosy, University of Benin ,Benin City, Nigeria

2 Department of Pharmaceutical Microbiology, University of Benin ,Benin City, Nigeria.

 

Tropical Journal of Pharmaceutical Research December 2007; 6(4): 809-813

ISSN: 1596-599

 

Abstract

Purpose: The antimicrobial activity of the 90 % ethanol extract of the aerial parts of Sida acuta Burm. F. (Malvaceae) was investigated in other to verify its claimed ethno medicinal use in the treatment of microbial infections.

Method: The antimicrobial activity of the extract was tested against standard strains and clinical isolates of some aerobic bacteria and a fungus using the Agar well diffusion method. Commercial antibiotics were used as positive reference standards to determine the sensitivity of the strains.

Results: The extracts showed significant inhibitory activity against standard strains and clinical isolates of Staphylococcus aureus, clinical isolates of Bacillus subtilis and Streptococcus faecalis. The MIC values obtained using the Agar-dilution test ranged from 5.0 mg/ml. – 10.0 mg/ml. Neither the concentrated extract nor its dilutions inhibited Esherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and Candida albicans

Conclusion: The results demonstrate that the crude extract of the aerial parts of Sida acuta has a narrow spectrum of activity and suggest that it may be useful in the treatment of infections caused by Gram positive aerobic bacteria.

Key words: Sida acuta, ethanol extract, antimicrobial activity.

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*Corresponding Author: E-mail: akerelej@uniben.edu

 

 
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Last updated: December 16, 2007