Tropical Journal of Pharmaceutical Research | |||||||||||||||
Official Journal of Pharmacotherapy Group | |||||||||||||||
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Research Article
Antimicrobial activity of the ethanol extract of the aerial parts of sida acuta burm.f. (malvaceae)
IE Oboh1, JO Akerele2* and O Obasuyi2 1 Department of Pharmacognosy, University of Benin ,Benin City, Nigeria 2 Department of Pharmaceutical Microbiology, University of Benin ,Benin City, Nigeria.
Tropical Journal of Pharmaceutical Research December 2007; 6(4): 809-813 ISSN: 1596-599
Abstract Purpose: The antimicrobial activity of the 90 % ethanol extract of the aerial parts of Sida acuta Burm. F. (Malvaceae) was investigated in other to verify its claimed ethno medicinal use in the treatment of microbial infections. Method: The antimicrobial activity of the extract was tested against standard strains and clinical isolates of some aerobic bacteria and a fungus using the Agar well diffusion method. Commercial antibiotics were used as positive reference standards to determine the sensitivity of the strains. Results: The extracts showed significant inhibitory activity against standard strains and clinical isolates of Staphylococcus aureus, clinical isolates of Bacillus subtilis and Streptococcus faecalis. The MIC values obtained using the Agar-dilution test ranged from 5.0 mg/ml. – 10.0 mg/ml. Neither the concentrated extract nor its dilutions inhibited Esherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and Candida albicans Conclusion: The results demonstrate that the crude extract of the aerial parts of Sida acuta has a narrow spectrum of activity and suggest that it may be useful in the treatment of infections caused by Gram positive aerobic bacteria. Key words: Sida acuta, ethanol extract, antimicrobial activity. ____________________ *Corresponding Author: E-mail: akerelej@uniben.edu
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Last updated: December 16, 2007 |