Synthesis, Analgesic, Anti-inflammatory and Antimicrobial Activities of Some Novel Pyrazoline Derivatives

SK Sahu*¹,  M Banerjee¹, A Samantray¹, C Behera¹ and MA Azam¹

¹University department Of Pharmaceutical Sciences, Utkal University, Bhubaneswar, Orissa, ²Department of Pharmaceutical Chemistry, J. S. S., College of Pharmacy, Ootacamund–643 001,India

Correspondence: E-mail: tutu_kh@yahoo.com  Tel: +91-9861536013

Tropical Journal of Pharmaceutical Research, June 2008; 7(2): 961-968

Abstract

Purpose: Microbial infections often produce pain and inflammation. Chemotherapeutic, analgesic and anti-inflammatory drugs are prescribed simultaneously in normal practice. The compound possessing all three activities is not common.The purpose of the present study was to examine whether molecular modification might result in detection of new potential antirheumatic drugs having antimicrobial activities.

Method: A series of novel 4-(5′-substituted aryl-4′, 5′-dihydropyrazole-3′-yl-amino) phenols 2a-f have been synthesized by treating substituted aryl-N-chalconyl amino phenols 1a-f with hydrazine hydrate. The starting materials were synthesized from p-aminoacetophenone. Their structures were confirmed by IR, ¹H NMR spectral data. The synthesized compounds were investigated for analgesic, ant-inflammatory and antimicrobial activities.

Result: The data reported in Tables 2, 3 & 4 shows that effect of variation in chemical structure on activity was rather unpredictable. Seldom did a particular structural modification lead to uniform alteration in activity in all tests. The substitution which appeared to be most important for high order of activity in the greatest number of test was the p-choloroaryl group. The introduction of p-nitro and p-hydroxy group in aryl moiety of the pyrazole analogs 2c and 2e produce compounds with potent analgesic, anti-inflamatory and, in a few cases, antimicrobial properties. 

Conclusion: The observed increase in analgesic, anti-inflammatory and antimicrobial activities are attributed to the presence of 4-NO₂, 2-OH and 4-Cl in phenyl ring at 5-position of pyrazoline ring of synthesized compounds. In some cases their activities are equal or more potent than the standard drugs. 

Keywords: Pyrazole, Analgesic, Anti-inflammatory, Antibacterial activity.