Tropical
Journal of Pharmaceutical Research,
September
2008; 7(3):
1051-1054
Abstract
Purpose:
The ethanol extracts obtained from the leaves, rootstock
and the combined formulation of endemic Salvia tigrina
Hedge & Hub.-Mor. (Labiatea) have been investigated for
their antifungal activities.
Method:
The antifungal activity of the extract was tested
against Candida species (C. albicans ATCC 10231, C.
tropicalis ATCC 13803 and C. guilliermondii ATCC 6260
and Cryptococcus species (C. neoformans ATCC 90112 and
C. laurentii 34142), Aspergillus flavus, Penicillium
frequentans, Botrytis cinerea, Geotrichum candidum,
Fusarium oxysporum and Alternaria alternara by the
visual broth macrodilution method. Ketoconazole was used
as a positive reference standard to determine the
sensitivity of the strains.
Results:
The minimum inhibitory concentration (MIC) ranged from
3.12 to 25 mg/mL. All the extracts exhibited a strong
antifungal effect against the fungal cultures. The
extracts exhibited greater antifungal effect against C.
albicans, C. neoformans and B. cinarea.
Conclusion:
The findings provide support for the use of this plant
in traditional medicine for fungal infections especially
against candidiasis.
Keywords:
Antifungal activity, Salvia tigrina, Plant extracts,
Minimum inhibitory concentration
