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Original
Research Article
Formulation of chitosan-based ciprofloxacin and
diclofenac film for periodontitis therapy
Mohammed Gulzar Ahmed*, NM Harish, R
Narayana Charyulu, Prabhakar Prabhu
Department of Pharmaceutics, NGSM Institute
of Pharmaceutical Sciences, Paneer
Deralakatte, Mangalore 574160, Karnataka,
India
*Corresponding
author:
Tel:
+91-824-2203991.9448401238, Fax: +91 824-2203992 E.mail:
mohammedgulzar@rediff.com
Received: 15 July
2008
Revised accepted: 10 October 2008
Tropical
Journal of Pharmaceutical Research, February
2009; 8(1):
33-41
Abstract
Purpose:
This study was designed to
develop and evaluate
chitosan films containing ciprofloxacin and diclofenac
sodium for the topical treatment of periodontitis.
Methods:
Chitosan films containing ciprofloxacin alone and in
combination with diclofenac sodium were prepared by
solvent casting method. Some of the drug-loaded films
were crosslinked with 2% gluteraldehyde for 2 and 4 h,
respectively. The films were then evaluated for their
physicochemical properties including weight variation,
thickness, tensile strength, in vitro release, stability
and antibacterial activity.
Results:
Mean weight and thickness data showed that the different
films were uniform. Tensile strength was maximum for
drug-free films and minimum for films containing the
highest amount of drug(s). In vitro drug release data
indicate that the films showed an initial burst release
followed by sustained release of the drug(s). Films
stored at refrigerated conditions exhibited slower
degradation rate. The drug-loaded films that were crosslinked
for 4 h had inhibitory effect on Staph mutans for up to
24 days.
Conclusion:
The study suggests that crosslinked chitosan film
containing ciprofloxacin and diclofenac is a potential
drug delivery device for the topical treatment of
periodontitis. Good
physicochemical properties were shown by the films.
Keywords:
Chitosan, Ciprofloxacin, Crosslinking, Diclofenac,
Films, Topical delivery, Periodontitis.
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