Department
of Pharmaceutics, S. G. R. S. College of
Pharmacy, Saswad, Pune. (MS), India 412301
*Corresponding
author:
.
Tel: +91-9923968989, Fax +91-2115-222213, E-mail-
ganesh_chaulang@rediffmail.com
Tropical
Journal of Pharmaceutical Research, February
2009; 8(1):
43-51
Abstract
Purpose:
This investigation was
carried out to determine if a solid dispersion of
furosemide in sodium starch glycolate (SSG) would
enhance the dissolution properties of the drug.
Methods:
Solid dispersion of furosemide in SSG was prepared in
ratios of 1:1 and 1 (furosemide):2 (SSG) by kneading
method. In each case, the solid dispersion was
characterized by Fourier transform infrared (FTIR)
spectroscopy, differential scanning calorimetry (DSC),
and X-ray diffraction (XRD) to ascertain if there were
any physicochemical interactions between drug and
carrier that could affect dissolution. Tablets
containing the solid dispersion were formulated and
their dissolution characteristics compared with
commercial furosemide tablets. The dissolution studies
were performed at 37 ± 0.5oC and 50 rpm in
simulated gastric fluid (pH 1.2).
Results:
FTIR spectroscopy, DSC, and XRD showed a change in
crystal structure toward an amorphous form of furosemide.
Dissolution data indicated that furosemide dissolution
was enhanced. XRD, DSC, FTIR spectroscopy and
dissolution studies indicated that the solid dispersion
formulated in 1:2 ratio showed a 5.40-fold increase in
dissolution and also exhibited superior dissolution
characteristics to commercial furosemide tablets.
Conclusion:
Solid dispersion technique can be used to improve the
dissolution of furosemide.
Keywords:
Solid dispersion, Furosemide, Sodium starch glycolate,
Dissolution enhancement, physicochemical
characterisation.
