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Original
Research Article
Investigation of In vitro Release Kinetics of
Carbamazepine from Eudragit® RS PO and RL PO
Matrix Tablets
Apurba Sarker Apu1*,
Atiqul Haque Pathan1, Dilasha Shrestha2,
Golam Kibria2 and Reza-ul Jalil2
1Department
of Pharmacy, East West University, Mohakhali,
Dhaka-1212, 2Faculty of Pharmacy, University
of Dhaka, Dhaka-1000, Bangladesh.
E-mail:
apurba2sarker@yahoo.com,
asa@ewubd.edu Tel:
00880-2-9882308, 00880-2-9887989 (Ext-115); Fax:
00880-2-8812336
Received:
30 July 2008
Revised accepted:
28 December 2008
Tropical
Journal of Pharmaceutical Research, April
2009; 8(2):
145-152
Abstract
Purpose:
The objective
of this research work was to prepare and evaluate the
effect of Eudragit RS PO and Eudragit RL PO polymers on
the physical property and release characteristics of
carbamazepine matrix tablets.
Methods:
Matrix tablets containing carbamazepine were prepared
with Eudragit® RS PO alone as the
rate-retarding polymer (coded batch series ‘A’) and also
with a combination of Eudragit® RS PO and RL
PO (coded batch series ‘B’). The tablets were
characterized for hardness as well as for carbamazepine
release. The release data were subjected to different
models in order to evaluate their release kinetics and
mechanisms.
Results:
The hardness of batch series ‘A’ matrix tablet was >160
kg/cm2 while for batch series ‘B’, it was
>170 kg/cm2. Carbamazepine tablets containing
only Eudragit RS PO showed very slow release (less than
6% in 8 h) but when Eudragit RL PO was blended with
Eudragit RS PO, the release rate improved significantly
to 44% in 24 h (p < 0.05). Drug release mechanism was a
complex mixture of diffusion and erosion.
Conclusion:
Carbamazepine matrix tablets of satisfactory hardness
were produced. Furthermore, by blending Eudragit RS PO
with Eudragit RL PO in the matrix, tablets of varying
release characteristics can be prepared.
Keywords:
Carbamazepine, Matrix tablet, Hardness, Eudragit®
RS PO, Eudragit® RL PO, Release kinetics. |
