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Original
Research Article
Optimization and Formulation of Orodispersible Tablets
of Meloxicam
Jashanjit Singh1*
and Rajmeet Singh2
1Department
of Pharmaceutics, Swift School of Pharmacy, Village-Gaagar
Sarai,Rajpura, 2Department of Pharmaceutics ,GHG
Khalsa College of Pharmacy, Guru Sar Sadhar,
Ludhiana,Punjab, India.
E-mail-
jas_nirman@rediffmail.com Tel: +91-9814819282,
+91-1762-653496 Fax: +91-175-2300711
Received:
29 September 2008
Revised accepted:
28 December 2008
Tropical
Journal of Pharmaceutical Research, April
2009; 8(2):
153-159
Abstract
Purpose:
The objective of this study was to formulate and
optimize an orodispersible formulation of meloxicam
using a 22 factorial design for enhanced
bioavailability.
Methods: The
tablets were made by non-aqueous wet granulation using
crospovidone and mannitol. A 22 factorial
design was used to investigate the amount of
crospovidone and taste masking, soothening hydrophilic
agent (mannitol), as independent variables, and
disintegration time as dependent response. Formulated
orodispersible tablets were evaluated for weight
variation, friability, disintegration time, drug
content, wetting time, water absorption ratio and in
vitro drug release.
Results: The
results show that the presence of a superdisintegrant
and mannitol is desirable for orodispersion. All the
formulations satisfied the limits of orodispersion with
a dispersion time of less than 60 sec. For example,
formulation F4 showed a disintegration time
of 32.1 sec, crushing strength of 4.93 kg/cm2,
drug content of 98.5% and fast drug release rate of
99.5% within 30 min, as compared with the conventional
tablet (49.5%) .
Conclusion:
It is feasible to formulate orodispersible tablets of
meloxican with acceptable disintegration time, rapid
drug release and good hardness, which could be amenable
to replication on an industrial scale.
Keywords:
Meloxicam, Orodispersion, Crosspovidone, Mannitol,
Factorial design, Tablet properties. |
