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Original
Research Article
Polymeric Recrystallized Agglomerates of Cefuroxime
Axetil Prepared by Emulsion Solvent Diffusion Technique
VB Yadav*1 and
AV Yadav2
1Govt.College
of Pharmacy, Vidyanagar, Karad, Dist-Satara (MS),
2Goa College of Pharmacy, 18th June
Road, Panaji, Goa, India
*Corresponding
author: E-mail: venkat_yadav3@rediffmail.com
Tel: +91-2164-271832
Received: 16 January
2009
Revised accepted: 18 April 2009
Tropical
Journal of Pharmaceutical Research, August 2009; 8(4):
361-369
Abstract
Purpose:
To study the effect of different polymers on the
solubility and dissolution rate of cefuroxime axetil (CFU)
prepared by emulsion solvent diffusion (ESD) technique.
Methods:
The ESD technique employed involved three test solvents:
first, substance dissolution medium-good solvent
(acetone); second, partial dissolution medium for the
substance-bridging liquid (dichloromethane), and third,
immiscible with the substance-poor solvent (distilled
water). The pure CFU and the prepared agglomerates were
characterized in terms of production yield, drug
content, solubility, in vitro release profile,
flowability, density, wettability, as well as by thin
layer chromatography (TLC), differential scanning
calorimetry (DSC), x-ray diffraction (XRD),
Fourier transforms infra red spectroscopy (FTIR) and
stability test.
Results:
DSC showed a decrease in the melting enthalpy indicating
disorder in the crystalline content. XRD also indicated
changes in crystallinity, FTIR revealed that there were
no chemical changes in the recrystallized agglomerates
while dissolution data demonstrated a marked increase in
the dissolution rate (>55 % in 45 min) compared with the
pure drug (35% in 45 min). The improvement in the
dissolution rate of CFU from optimized crystal
formulation was attributed to the wetting effect of the
polymers, change in drug crystallinity, altered surface
morphology and micronization. The recrystallized
agglomerates also exhibited higher wettability and
flowability.
Conclusion:
The optimised recrystallized agglomerates exhibited good
solubility, wettability, dissolution rate and other
physicochemical properties compared to the unmodified
CFU.
Key
words: Cefuroxime axetil; Recrystallized
agglomerates; Solubility; Dissolution; Physicochemical
properties. |
