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Original
Research Article
Antinociceptive and Anti-Inflammatory Effects of Solvent
Extracts of Tagetes erectus Linn (Asteraceae)
NV Shinde*, KG Kanase, VC
Shilimkar, VR Undale and AV Bhosale
SGRS
College of Pharmacy, Department of Pharmacology, Pune
University, Saswad, Tal-Purandar, Pune 412301, India
*Corresponding
author: E-mail: nealrose123@gmail.com
Tel: +91 (02115) 222212; Fax: +91 (021)
222213
Received: 30 December
2008
Revised accepted: 18 May 2009
Tropical
Journal of Pharmaceutical Research, August 2009; 8(4):
325-329
Abstract
Purpose:
Traditionally, the leaves of Tagetes erectus L. are used
in India for the alleviation of pain and inflammation.
The objective of this study was to investigate the
antinociceptive and anti-inflammatory activities of this
plant material in an animal model.
Methods:
The
chloroform, methanol and ether extracts of the leaves of
Tagetes erectus L. (family: Asteraceae) were tested
against acetic acid-induced writhing in mice and
carrageenan-induced paw oedema in rats in order to
assess their antinoceciptive and anti-inflammatory
activities, respectively. The doses administered
intraperitoneally (I.P.) ranged from 100 to 400 mg/kg
body weight, and acetylsalicylic acid (ASA) and
phenylbutazone were the reference standards for the
antinoceciptive and anti-inflammatory tests,
respectively.
Results:
The
extracts showed antinociceptive and anti-inflammatory
properties at doses between 200-400 mg/kg. They
inhibited significantly (P < 0.005), in a dose-dependant
manner, induced writhing reflexes in mice. The
antinoceciptive effect was comparable to that of ASA
which served as the reference standard. Similarly, the
extracts significantly (P <0.05) reduced carragenan-induced
paw oedema in rats and the reduction in paw volume was
comparable to that of the reference standard (phenylbutazone).
It also increased pain threshold in the oedematous right
hind limb paw of the rats.
Conclusion:
The results obtained show that the extracts of Tagetes
erectus L. (Asteraceae) has antinociceptive and
anti-inflammatory properties. This finding provides a
basis for the traditional use of the plant material.
Keywords:
Tagetes erectus, Antinociceptive, Anti-inflammatory. |
