Effect of Hydroxypropyl
Methylcellulose and Ethyl Cellulose Content on Release
Profile and Kinetics of Diltiazem HCl from Matrices
R Enayatifard, M Saeedi, J Akbari and Y Haeri
Tabatabaee
Department of
Pharmaceutics, Faculty of Pharmacy, Mazandaran
University of Medical Sciences, Sari, Iran
*Corresponding author:
E-mail:
enayatifard_r@yahoo.com Tel:
+98-151-3543082; Fax: +98-151-3543084
Received: 27 February
2009
Revised accepted: 21 May 2009
Tropical
Journal of Pharmaceutical Research, October 2009; 8(5):
425-432
Abstract
Purpose:
To
develop a oral controlled matrix drug delivery system
for a highly water soluble drug, diltiazem HCl, and
investigate its drug release mechanism.
Method:
Diltiazem HCl was chosen because of its high water
solubility. Tablets containing the drug were prepared by
direct compression method using different matrix ratios
of ethyl cellulose (EC) and hydroxypropyl
methylcellulose (HPMC). The formulations were evaluated
in vitro for their dissolution characteristics over a
period of 8 h. Drug release was analysed according to
various release kinetic models.
Results:
The results showed that these polymers slowed down the
release of diltiazem HCl from the matrices. In the
presence of EC, increasing the concentration of HPMC
decreased the release rate of diltiazem. Furthermore,
incorporation of EC in tablets with HPMC as the matrix
was found to control drug release. Kinetic analysis
showed that drug release from three of the formulations
was adequately described by zero order model.
Conclusion:
The formulations developed could potentially be used for
controlled delivery of highly soluble drugs such as
diltiazem HCl.
Key words:
Matrix tablets; Diltiazem HCl; Hydroxypropyl
methylcellulose; Ethylcellulose; Drug release
