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Research Article

Antitubercular and Phytochemical Investigation of Methanol Extracts of Medicinal Plants Used by the Samburu Community in Kenya

Richard M Mariita¹, Callistus KPO Ogol², Nick O Oguge³ and Paul O Okemo¹*

¹Department of Plant and Microbial Sciences, ²Zoological Sciences Department, Kenyatta University, PO Box 43844, Nairobi 00100, ³ Earthwatch Institute Kenya, PO Box 47840-00100, Nairobi, Kenya.

*Corresponding author: E-mail: okemo1952@yahoo.com Tel: +254-722942072; Fax: +254-020-810759

Received: 12 February 2010 Revised accepted: 12 June 2010

Tropical Journal of Pharmaceutical Research, August 2010; 9(4): 379-385

Abstract

Purpose: To determine the potential benefits of nine medicinal plants used by the Samburu community for the treatment of tuberculosis.

Methods: The extract was tested against four strains of Mycobacteria namely; Mycobacterium tuberculosis (Mtb), M. Kansasii (Mk), M. fortuitum (Mf), and M. smegmatis (Ms) using BACTEC MGIT 960 system. The crude extracts were also analyzed for the presence of phytochemical constituents.

Results: Both the extracts of Scadoxus multiflorus and Acacia nilotica showed strong antimycobacterial activity against the four tuberculosis-causing strains. Eurphobia scarlatina was the most active against both the slow (Mtb and Mk) and the fast (Mf and Ms) growers with Zero GUs at 0.5mg/ml. Phytochemical screening indicated presence or absence of tannins, saponins and flavonoids, terpenoids, cardiac glycosides and alkaloids in the extracts.

Conclusion: The data suggest that some of the methanol extracts could be a rich source of antituberculosis agents. The results further show that there is some merit in the use of some of the plants studied in alternative medical practice. Pharmacological and toxicological studies of the active plants are still under investigation.

Keywords: Medicinal plants, Methanol extract, Antituberculosis, Samburu.